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OTC or over the counter Vitamins and Supplements: Neurobion B1 B6 B12 Ampavit B12 TP B100 Complex Merck Ampavit Cyanocobalamin is a man-made form of vitamin used to treat low levels (deficiency) of this vitamin. Vitamin B12 helps your body use fat and carbohydrates for energy and make new protein. It is also important for normal blood, cells, and nerves. Most people get enough of this vitamin in their diet, but a deficiency may occur in certain health conditions (e.g., poor nutrition, stomach/intestinal problems, infection, cancer). Serious vitamin B deficiency may result in anemia, stomach problems, and nerve damage.

Why is B12 used?
Cyanocobalamin
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B124u: Anemia due to B12 deficiency conditions; in the complex therapy for iron and posthemorrhagic anemia; aplastic anemia caused by toxic substances and drugs; liver disease (hepatitis, cirrhosis); funicular myelosis; polyneuritis, radiculitis, neuralgia, amyotrophic lateral sclerosis; children cerebral palsy, Down syndrome, peripheral nerve injury; skin diseases (psoriasis, photodermatosis, herpetiformis dermatitis, neurodermatitis); to prevent and treat symptoms of deficiency of vitamin B12 (including the application of biguanide, PASA, vitamin C in high doses); radiation sickness

Methylcobalamin. This the most bio-available form of Vitamin B12. It differentiates from the rest because it has Methyl- group (CH3).

Vitamin B12 benefits your mood, energy level, memory, heart, skin, hair, digestion and more. Vitamin B12 is also an essential vitamin for addressing adrenal fatigue, multiple metabolic functions — including enzyme production, DNA synthesis and hormonal balance — and maintaining healthy nervous and cardiovascular systems.

+Helps Maintain Energy Levels. …
+Prevents Memory Loss and Lowers Risk of Neurodegenerative Disease. …
+Boosts Mood and Helps the Nervous System to Properly Function. …
+Plays a Role in Maintaining Heart Health. …
+Needed for Healthy Skin and Hair. …
+Aids in Digestion. …
+Needed for a Healthy Pregnancy.

Vitamin B12 is a water soluble vitamin essential in the human diet. There are 12 different types of B-Vitamin,

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Vitamin B12 benefits the central nervous system in many important ways: It helps maintain the health of nerve cells — including those needed for neurotransmitter signaling — and helps form the protective covering of nerves, called the cell’s myelin sheath. This means that when vitamin B12 levels are low, almost every cognitive function can suffer.

Vitamin B12, sometimes also called Methylcobalamin, also helps with digestion and heart health, so a deficiency can lead to both digestive disorders and an increased risk for heart disease.

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Below is a brief research on Methylcobalamin.

Methylcobalamin. B12, also known as cobalamin, naturally exists in the body in the form of Methylcobalamin.

Only adenosylcobalamin (AdeCbl) and methylcobalamin (MetCbl) are active within the human body. You’ll find MetCbl mainly in your blood plasma, cytosol cells, and certain body fluids (like cerebral spinal fluid), and AdeCbl in cellular tissues where it is stored in the mitochondria. In fact, the benefits of B12 all boil down to two biochemical reactions:

The conversion of methylmalonyl-coenzyme A to succinylcholine coenzyme A (by methylmalonyl-CoA mutase, with adenosylcobalamin as a cofactor), and the remethylation of homocysteine to methionine (with methylcobalamin being a cofactor for methionine synthase).

Methylcobalamin

Methycobal
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(also Mecobalamin, MeCbl, MetCbl, MetB12, MeB12, or Methyl B12)

Methylcobalamin, the kingpin, one of the two active, natural forms of B12. It helps reduce homocysteine concentrations and generates SAMe (S-adenosyl methionine), the most important methyl donor in your body, supplying methyl groups for crucial chemical reactions to help maintain your health.

Where methyl B12 shows its greatest utility is with people suffering form degenerative neurological symptoms, where it’s often the only promising treatment. It bypasses several potential issues in the absorption cycle and helps relieve or completely reverse symptoms.

High doses of methylcobalamin have been used to treat multiple sclerosis (improved visual and auditory symptoms, not motor ones), amytropic lateral sclerosis, Parkinson’s, and may help regenerate nerves and treat peripheral neuropathies. People with Alzheimer’s noticed an improvement in memory and intellectual function when given this form of B12.

In fact, MetCbl is so effective — in numerous areas — that it is used almost exclusively in Japan to treat B12 deficiency.
Cyanocobalamin: it takes more than 48 hours for cyanocobalamin B12 to eventually convert to usable methylcobalamin, and even then only a small amount is converted.
Hydroxocobalamin is also an inactive form of B12, but it is better than cyanocobalamin because it doesn’t contain any cyanide, therefore bypassing the need for decyanation and preserving the glutathione. It also has to be reduced from state +3 to +1 before it can become either Methylcobalamin or AdeCobalamin.